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What is MODY  |  Testing and Diagnosis  |  Disease Management  |  Resources

 

Disease Management

 

The major treatment goal for MODY is the same as that for other forms of diabetes – to keep blood sugars as close to normal as possible, while minimizing other risk factors. In many cases, these goals can be achieved more easily for MODY patients than for patients with types 1 and 2 diabetes.

 

The tools available for managing MODY include genetic blood testing to help diagnose MODY, changes in diet and exercise, use of oral hypoglycemic agents, or use of insulin injections, depending on the type of MODY that the patient has. Being properly diagnosed with MODY may mean that patients are able to switch from insulin injections to oral medications or from oral medications to no medication at all. Other forms of MODY may still require insulin injections.

 

The below figure lists the typical course of treatment for the six most common subtypes of MODY.

 

Diagnostic Algorithm

 

Because the treatment options and prognoses for MODY subtypes differ from each other and from those for type 1 and 2 diabetes, it is important to correctly diagnose MODY. Genetic testing allows for differentiation of MODY from type 1 and type 2 diabetes and between common subtypes, facilitating selection for the most appropriate treatment.1 Testing for MODY should be seriously considered for diabetics of any age with non-ketotic insulin-sensitive hyperglycemia or with a family history of diabetes.2

  1. Timsit, J., et al., (2005) Treat Endocrinol, 4:9-18.
  2. Hattersley, A., et al., (2006) Pediatric Diabetes, 7:352–360.
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